Our Services
Discover how our alternative models can accelerate your product development with safety and regulatory compliance.
Multi-model portfolio
Regulatory focus
Scientific agility
Personalized service
Zebrafish
(Danio rerio)
Model vertebrate for developmental toxicology, neurobehavior, and drug safety studies. 70% genes homologous to humans.
Applications:
- Acute toxicity (FET - OECD 236)
- Embryonic malformations
- Neurotoxicity
- Cardiotoxicity
- Embryotoxicity
- Redox biology biomarkers
Sectors served:
Zebrafish (Danio rerio) is a vertebrate model widely used in toxicological studies due to its high genetic homology with humans (approximately 70%), embryonic transparency, and rapid external development. Allows acute toxicity assessments following the OECD 236 protocol (Fish Embryo Acute Toxicity Test - FET), being ideal for compound screening in early R&D phases. About 84% of genes linked to human diseases are also present in Zebrafish. These small organisms are true allies in research.
Regulatory basis:
Fruit Fly
(Drosophila melanogaster)
Widely validated invertebrate model, with a strong genetic basis and high conservation of biological pathways, ideal for functional toxicity, neurodegeneration, and genotoxicity studies.
Applications:
- Functional neurotoxicity
- Genotoxicity
- Longevity and aging
- Redox biology biomarkers
- Acute and chronic toxicology
- Dose-response assessment
- Larval development
- Mitochondrial dysfunction and cell death
- Bioactive compound screening
- Nanotoxicology and co-exposure
Sectors served:
Drosophila melanogaster has a completely sequenced genome and shows high conservation of essential metabolic pathways, making it a highly relevant model for toxicological studies. Approximately 75% of genes associated with human diseases have homologs in this organism, reinforcing its applicability in translational research. This model is especially effective for assessing oxidative stress, functional neurotoxicity, and chronic effects, allowing the analysis of biomarkers such as SOD, CAT, GST, and lipid peroxidation (TBARS). In addition, its high reproductive rate, short life cycle, and low operational cost make Drosophila an efficient, scalable, and cost-effective tool for toxicological screening and mechanistic studies.
Regulatory basis:
Artemia salina
Microcrustacean
Crustacean widely used for initial screening of acute environmental and pharmacological toxicity with rapid response (24-48h).
Applications:
- Acute environmental toxicity
- Bio-inputs screening
- Pharmacological screening
- Nanomaterials evaluation
- Ecotoxicology
Sectors served:
Artemia salina is a microcrustacean widely recognized as a rapid screening model for acute toxicity, providing results within 24 to 48 hours. Its short life cycle, ease of cultivation, and high experimental reproducibility make this organism an efficient tool for preliminary safety assessment. It is especially suited for initial screening of chemical compounds, agricultural bio-inputs, and nanomaterials, allowing samples to be prioritized before more complex and costly assays. In addition, its use is widely accepted in ecotoxicology studies and environmental monitoring, contributing to the risk assessment of substances in different environmental matrices.
Regulatory basis:
Biochemical Analysis
(Redox Biology)
Investigation of toxic effects at cellular and molecular level, focusing on oxidative processes and antioxidant response, enabling a mechanistic understanding of the biological effects of different compounds.
Applications:
- Carbonylated proteins
- Lipid peroxidation (TBARS)
- Antioxidant enzymes (SOD, CAT, GST)
- Total thiol content
- Oxidative DNA damage
- Total ROS
Sectors served:
Biochemical analyses complement in vivo assays, providing essential mechanistic data on toxicological effects at the molecular level. By evaluating oxidative stress biomarkers, it is possible to identify early changes in cellular homeostasis and antioxidant defense systems. Markers such as superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), as well as lipid peroxidation levels (TBARS) and oxidative DNA damage are analyzed, allowing an integrated assessment of the biological response to the tested compound. This approach is essential for building a complete toxicological profile, supporting decision-making in preclinical studies, product development, and regulatory strategies.
Regulatory basis:
Need a customized assay?
Our team develops custom protocols to meet specific R&D, regulatory registration or product validation demands.
